Antibody Technology Platforms

DuoHexaBody®

DuoHexaBody® combines our DuoBody® and HexaBody® technologies, creating bispecific antibodies with target-mediated enhanced hexamerization. 
Illustration of DuoHexaBody, a ÐǺ£ÆåÅÆ antibody technology platformIllustration of DuoHexaBody, a ÐǺ£ÆåÅÆ antibody technology platform
OverviewReferences GlossaryOther Technologies

The DuoHexaBody® platform is ÐǺ£ÆåÅÆ’s proprietary technology that combines the dual targeting of our DuoBody® technology with the enhanced potency of our HexaBody® technology, creating bispecific antibodies with target-mediated enhanced hexamerization. 

Schematic of DuoHexaBody molecules
Schematic of DuoHexaBody molecules
Schematic representation of mechanism of action of the DuoHexaBody® platform.
Figure 1: Schematic representation of mechanism of action of the DuoHexaBody® platform.
References
Oostindie et al., Blood Cancer J. 10(3):30 (2020).  
DuoHexaBody Glossary
Hexamerization
The process of IgG antibodies clustering in such a way that they form hexameric ring structures through interactions via their Fc-domains. These hexamers constitute the most optimal conformation for the binding of C1q, which initiates activation of the classical complement pathway. 
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HexaBody

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